Home
Introduction of the course
Résumés of the Course Leaders
Program July, 10-14 (2006)
Course Registration

Innovation in Biopharmaceutical Process Development and Manufacturing

Program in detail

A comprehensive course overview can be downloaded as a PDF-file. In the following, a detailed course program is presented:

1. Introduction of Manufacturing Processes for Biopharmaceuticals
• Introduction to the Case Studies
  Jose Coco Martin
• Overview of the upstream part of manufacturing of biopharmaceuticals, PAT and quality systems (Q8-Q10)
  Coen Beuvery
• Introduction of PAT in a pharmaceutical company
  Ben Langelaan, Organon, The Netherlands
2. Expression Systems
• Expression in prokaryotic cells and optimizing recombinant microbial fermentation processes
  Karl Bayer, Key Note Speaker,
  University of Natural Resources and Applied Sciences, Austria
• Mammalian cell expression systems
  Jose Coco Martin
• Baculo virus expression system
  Just Vlak, Wageningen University, The Netherlands
3. Cell Biology in relation to controllable Reactor Parameters
• Cell physiology apoptosis, proliferation, metabolism
  Mike Butler, Key Note Speaker,
  University of Manitoba, Winnipeg, Canada
• Relation reactor conditions and product quality
  Dirk Martens
• Post translation modifications under various reactor conditions
  Chantal Christis, University of Utrecht, The Netherlands
• Product characterization
  Marc Sutter, University of Utrecht, The Netherlands
• Case studies
4. Control Strategies, Reactor Design and In homogeneities
• Control strategies for cultivation processes in bioreactors
  Ton van Boxtel
• Bioreactor design
  Hans Tramper, Key Note Speaker,
  Wageningen University, The Netherlands
• Computational fluid dynamics applied in bioreactors
  Gino Baart, Netherlands Vaccine Institute, Bilthoven
• Excursion
5. Advanced process monitoring and novel Biosensors
• PAT: creating a paradigm
  Eric van Sprang and Henk-Jan Ramaker,
  TIPb, Amsterdam, The Netherlands
• Multivariate data acquisition
  Eric van Sprang and Henk-Jan Ramaker,
  TIPb, Amsterdam, The Netherlands
• Multivariate design
  Eric van Sprang and Henk-Jan Ramaker,
  TIPb, Amsterdam, The Netherlands
• Process analyzers
  Eric van Sprang and Henk-Jan Ramaker,
  TIPb, Amsterdam, The Netherlands
• Process monitoring and control
  Eric van Sprang and Henk-Jan Ramaker,
  TIPb, Amsterdam, The Netherlands
• Kaizen and knowledge management tools (continuous improvement)
  Eric van Sprang and Henk-Jan Ramaker,
  TIPb, Amsterdam, The Netherlands
• Workshop PAT and data management
  Eric van Sprang and Henk-Jan Ramaker,
  TIPb, Amsterdam, The Netherlands
6. Models for Process Understanding
• From genome to proteome in the cell to be cultivated
  Gino Baart, Netherlands Vaccine Institute, Bilthoven
• Grey models used for process understanding
  Johan Westerhuis, University of Amsterdam, The Netherlands
• Engineering of cell lines
  Stephan Goletz, Glycotope, Berlin, Germany
• Presentation case studies